Insecticidal activity of oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite and their modulations of voltage-gated sodium channels
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概要
- 論文の詳細を見る
Insecticidal bioassays on Plutella xylostella (Linneaus) of an oxadiazine insecticide indoxacarb and its N-decar-bomethoxylated metabolite (DCJW), and their modulation of voltage-gated sodium channels in rat dorsal root gan-glion neurons were examined. No significant difference was observed in insecticidal activity between indoxacarb and DCJW in ingestion and contact tests. In patch-clamp experiments, both indoxacarb and DCJW suppressed the peak sodium currents in a time- and dose-dependent manner. DCJW at 1 μM blocked the sodium currents to-62.7±3.0% (n=5) of the control after 25 min of bath application. In contrast, in the presence of 1 μM indoxacarb, currents were blocked to 4.5±0.6%(n=4) of control. Thus, the potency of DCJW in blocking sodium currents was higher than that of indoxacarb in rat dorsal root ganglion neurons.
- 日本応用動物昆虫学会の論文
- 2001-08-25
著者
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KONO Yoshiaki
Institute of Agriculture and Forestry, University of Tsukuba
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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Shono Toshio
Institute of Agriculture and Forestry, The University of Tsukuba
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Shono Toshio
Institute Of Agriculture And Forestry University Of Tsukuba:(present Address)department Of Entomolog
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Shono Toshio
Institnte Of Agriculture And Forestry University Of Tsukuba
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Nagata K
Nagoya Univ. Nagoya Jpn
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Nagata Keiichi
Brain Science Institute The Institute Of Physical And Chemical Research (riken):(present Address)dep
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Tsurubuchi Yuji
Institute of Agriculture and Forestry, University of Tsukuba
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Karasawa Akira
Institute of Agriculture and Forestry, University of Tsukuba
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Tsurubuchi Y
Univ. Tsukuba Ibaraki Jpn
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kono Yoshiaki
Institute Of Agriculture And Forestry University Of Tsukuba
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