Inhibitory Effect of Olopatadine Hydrochloride on the Sneezing Response Induced by Intranasal Capsaicin Challenge in Guinea Pigs
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概要
- 論文の詳細を見る
To investigate the possible inhibitory effect of olopatadine hydrochloride (olopatadine), an antiallergic drug, on the tachykinin-mediated nasal responses, we examined the effect of olopatadine on the sneezing and the nasal rubbing responses induced by intranasal capsaicin challenge in guinea pigs. Olopatadine (10 mg/kg, p.o.) inhibited the sneezing response by 57% without affecting the nasal rubbing one. The antihistamines chlorpheniramine and clemastine did not affect the responses. Morphine caused the inhibition of both responses, which was antagonized by naloxone. These results suggest that olopatadine inhibits the sneezing response by the inhibition of the tachykinin release and not by its antihistaminic action.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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石井 昭男
協和発酵医薬研
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KARASAWA Akira
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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ISHII Akio
Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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Karasawa Akira
Department Of Bioscience Faculty Of Science And Technology Kwansei Gakuin University
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KAISE Toshihiko
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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KAISE Toshihiko
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
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AKAMATSU Yukino
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
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ISHII Akio
Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd
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Kaise Toshihiko
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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ISHII AKIO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Ishii A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Deparment Of Pharmacology Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Akamatsu Yukino
Department Of Pharmacology Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ishii Akio
Department Of Mechanical Science And Bioengineering Graduate School Of Engineering Science Osaka University
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石井 昭男
協和発酵工業(株)医薬研究所
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ISHII Akio
Toxicological Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
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