Antidiarrheal Effects of Zaldaride Maleate After Oral, Intravenous and Subcutaneous Administration to Rats
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概要
- 論文の詳細を見る
The antidiarrheal action of zaldaride maleate (ZAL) after oral, intravenous and subcutaneous administration was examined to determine whether ZAL acts systemically or locally in the intestine of rats. Oral administration of ZAL inhibited castor oil- and 16, 16-dimethyl prostaglandin E2-induced diarrhea; however, intravenous or subcutaneous administration of ZAL was ineffective. When ZAL was orally administered, the area under the plasma concentration time curve of the compound was lower than that of ZAL following intravenous or subcutaneous administration at the maximum doses studied. The antidiarrheal effect of ZAL was not dependent on its plasma concentration level. These results suggest that ZAL acts locally in the intestinal tract in rats.
- 社団法人 日本薬理学会の論文
- 1999-12-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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OHMORI Kenji
Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., L
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Ohmori K
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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HORIKOSHI Kaori
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Kogyo Co., Ltd.
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AIKAWA Nobuo
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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Aikawa N
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Aikawa Nobuo
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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MAEDA Hiroshi
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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KOBAYASHI Hiroyuki
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Ohmori Kenji
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Horikoshi Kaori
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kobayashi H
Department Of Earth & Spece Science Graduate School Of Science Osaka University
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Kobayashi H
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Horikoshi Kaori
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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