Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats

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概要

• 論文の詳細を見る

• The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug.5-Hydroxytryptamine(10mg/kg, s.c.), neostigmine(0.3mg/kg, s.c.)and nicotine(1.0mg/kg, s.c.)increased fecal pellet output.Zaldaride(≥30mg/kg, p.o.)reduced these increases in facal pellet outputs.Loperamide(10mg/kg, p.o.)inhibited fecal pellet output induced by 5-hydroxytryptamine and neostigmine but not nicotine.Under normal conditions, zaldaride and loperamide did not affect fecal pellet output at doses used in these studies.In conclusion, zaldaride may inhibit increases in fecal pellet output induced by hyperpropulsion of the gastrointestinal tract without causing constipation as a side effect.

• 社団法人 日本薬理学会の論文
• 2000-04-01

著者

• AIKAWA Nobuo

  Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt

• Aikawa Nobuo

  Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.

• Ohmori Kenji

  Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.

関連論文

• Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16, 16-Dimethyl Prostaglandin E_2-Induced Intestinal Ion Secretion in Rats
• Comparison of the Antidiarrheal Effects of Zaldaride Maleate and Its Optical Isomers in Rats
• Gender Differences in the Antidiarrheal Effect of Zaldaride Maleate in Rats
• Antidiarrheal Effects of Zaldaride Maleate After Oral, Intravenous and Subcutaneous Administration to Rats
• Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Visceral Pain Reflex Induced by Small Intestinal Distention in Anesthetized Rats
• Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats

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