Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16, 16-Dimethyl Prostaglandin E_2-Induced Intestinal Ion Secretion in Rats
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概要
- 論文の詳細を見る
The effect of zaldaride, a calmodulin inhibitor, on 16, 16−dimethyl prostaglandin E2(dmPGE2)−induced intestinal ion secretion was investigated in rats.Zaldaride inhibited the dmPGE2−induced increase in water content in the colon, but not that in the small intestine.In the colonic mucosa, zaldaride attenuated the dmPGE2−induced short−circuit current;however, it did not affect the forskolin or dibutyryl cAMP−induced effect.These results suggest that zaldaride inhibits dmPGE2−induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin−dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.
- 社団法人 日本薬理学会の論文
- 2000-07-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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OHMORI Kenji
Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., L
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KARASAWA Akira
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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AIKAWA Nobuo
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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Aikawa N
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Aikawa Nobuo
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Ohmori Kenji
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Drug Department Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmoro Kenji
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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