Antioxidant Effects of Calcium Antagonists in Rat Brain Homogenates
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概要
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We studied the antioxidant activities of calcium antagonists against autoxidation in rat brain homogenates.The homogenates were incubated for 30 min at 37℃ with or without a calcium antagonist and subsequently assayed for lipid peroxide content. Percent inhibition of the lipid peroxidation was used as an index of the antioxidant effect. Dihydropyridine calcium antagonists exhibited concentration-dependent (3-300 μmol/l) inhibitory effects against lipid peroxidation. The relative order of antioxidant potency and associated IC_<50> values (μmol/l) of the calcium antagonists for inhibition of the lipid peroxidation were as follows : nifedipine (51.5)>barnidipine(58.6)>benidipine (71.2)>nicardipine (129.3)>amlodipine (135.5)>nilvadipine (167.3)>nitrendipine (252.1)>>diltiazem (>300)=verapamil (>300). These results suggest that some dihydropyridine calcium antagonists show antioxidant properties. The antioxidant effects of the calcium antagonists may contribute to their pharmacological actions.
- 公益社団法人日本薬学会の論文
- 2000-06-01
著者
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NAGASHIMA Ken
Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., L
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OHMORI Kenji
Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., L
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YAO Kozo
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd
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OHNO Tetsuji
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd
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Yao K
Biomedical Research Laboratories
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Ohmori K
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Ina Yazuhiro
Biomedical Research Laboratories
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Ina Yasuhiro
Pharmaceutical Research Center Kyowa Hakko Kogyo Co. Ltd.
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Ina Yasuhiro
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Ohno T
Biomedical Research Laboratories
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Nagashima K
Osaka Univ. Fuc. Medicine Suita Jpn
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Ohno T
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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大野 智子
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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Ohno T
Laboratory Of Medicinal Resources School Of Pharmacy Aichi Gakuin University
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Ohmori Kenji
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohno Tomie
Health And Welfare Course Hokkaido University Of Education Asahikawa Campus
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Ohno Tetsuji
Biomedical Research Laboratories
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INA Yazuhiro
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Lt
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Nagashima Ken
Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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