Degradation Kinetics of the New Antibacterial Fluoroquinolone Derivative, Orbifloxacin, in Aqueous Solution
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概要
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The degradation kinetics of orbifloxacin [1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid] was investigated as a function of pH (1.5-10.5), temperature (100-120℃) and buffer concentration (0.05-0.2M) by means of high-performance liquid chromatography.The degradation of orbifloxacin in aqueous solution followed apparent first-order kinetics under all experimental conditions. No appreciable effect of buffer on the degradation of orbifloxacin was observed for any of the buffer species used in this study. The log k-pH profiles indicated specific-acid and specific-base catalyses and there were inflection points near pH 6 and 9 corresponding to the pK_<a1> and pK_<a2> values. From the Arrhenius plots, the activation energies for k'_H, k'_<H_2O>, k_<H_2O>, k''_<H_2O> and k''_<OH>were found to be 31.9,36.9,23.5,26.5 and 19.0 kcal/mol, respectively. Arrhenius data obtained from this study showed that the degradation of orbifloxacin at room temperature negligible at all pH values studied conditions (pH 1.5-10.5).
- 公益社団法人日本薬学会の論文
- 1995-06-15
著者
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Ohno T
Biomedical Research Laboratories
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Ohno T
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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大野 智子
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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Ohno T
Laboratory Of Medicinal Resources School Of Pharmacy Aichi Gakuin University
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Ohno Tomie
Health And Welfare Course Hokkaido University Of Education Asahikawa Campus
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Ohno Tetsuji
Biomedical Research Laboratories
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Matsukura H
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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森村 徹
Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,
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松倉 迅
Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,
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延原 好文
Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,
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森村 徹
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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延原 好文
Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt
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