Thermodegradation Kinetics of the New Antibacterial Fluoroquinolone Derivative, Sparfloxacin, in Aqueous Solution

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概要

• 論文の詳細を見る

• The degradation kinetics of sparfloxacin (5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid) were examined as functions of pH (1.0-10.5), temperature (100-120℃) and buffer concentration (0.01-0.05 M).The degradation kinetics for sparfloxacin in aqueous solution followed a pseudo-first-order reaction under all experimental conditions. No appreciable effect of buffer species on the degradation of sparfloxacin was observed within the experimental conditions. The log k-pH profiles showed specific-acid catalysis at a pH below 4.0,and there were inflection points near pH 6 and 9 corresponding to the pK_<a1> and pK_<a2> values. Arrhenius data in this study showed that the degradation of sparfloxacin was negligible at room temperature between pH 1.0-10.5.

• 公益社団法人日本薬学会の論文
• 1996-08-15

著者

• Matsukura H

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

• MORIMURA Tetsu

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• NOBUHARA Yoshifumi

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• MATSUKURA Hayashi

  Department of Chemical Analysis, Pharmaceutical Research Laboratories, Dainippon Pharmaceutical Co.,

• 森村 徹

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

• 延原 好文

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

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• Thermodegradation Kinetics of the New Antibacterial Fluoroquinolone Derivative, Sparfloxacin, in Aqueous Solution

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