Enzymatic Hydrolysin in Organic Solvents for Kinetic Resolution of Water-Insoluble α-Acyloxy Esters with Immobilized Lipases

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概要

• 論文の詳細を見る

• Enantioselective hydrolysis of water-insoluble α-acyloxy esters, (±)-5 and (±)-6,was carried out using lipases immobilized with Celite or a synthetic prepolymer (ENTP-4000 or ENT-4000) in a water-saturated organic solvent to produce chiral intermediates, (2S, 3S)-5 and (2S, 3R)-4,for the synthesis of diltiazem hydrochloride 1 and (-)-indolmycin 2,respectively. Furthermore, enantioselective hydrolysis of (±)-6 using lipid-lipase aggregates in water-saturated organic solvent was also found to give (2S, 3R)-4.

• 公益社団法人日本薬学会の論文
• 1997-02-15

著者

• AKITA Hiroyuki

  School of Pharmaceutical Science, Toho University

• Akita H

  Toho Univ. Chiba Jpn

• Akita Hiroyuki

  School Of Pharmaceutical Science Toho University

• Matsukura Hiroko

  RIKEN

• Akita Hiroyuki

  School Of Parmaceutical Sciences Toho University

• UMEZAWA Isao

  Riken Institute (The Institute of Physical and Chemical Research)

• Matsukura H

  Department Of Chemical Analysis Pharmaceutical Research Laboratories Dainippon Pharmaceutical Co. Lt

• Umezawa I

  Riken Institute (the Institute Of Physical And Chemical Research):(present Address)fuji Yakuhin Co.

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