Enantioselective Synthesis of (2R, 4'R, 8'R)-α-Tocopherol (Vitamin E) Based on Enzymatic Function

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概要

• 論文の詳細を見る

• Syntheses of (S)-chroman-2-carboxaldehyde congener 1 and (S)-chiral isoprene unit 3 were achieved based on the enzymatic acetylation of (±)-chroman-2-methanol 6 and (±)-(2,3)-anti-2-methyl-3-(p-methoxyphenyl)-1,3-propane diol 12,respectively. Synthesis of the side-chain part corresponding to (3R, 7R)-3,7,11-trimethyldodecan-1-ol 27 was achieved by the couping reaction of (S)-3 and (R)-3,7-dimethyloctyl iodide 4. The Witting reaction of (3R, 7R)-phosphonium salt 2 derived from (3R, 7R)-27 and (S)-1 gave the olefin 28 which was subjected to cat-alytic hydrogenation to afford (2R, 4' R, 8' R)-α-tocopherol.

• 公益社団法人日本薬学会の論文
• 2000-02-01

著者

• AKITA Hiroyuki

  School of Pharmaceutical Science, Toho University

• Kato K

  Toho Univ. Chiba Jpn

• Kato K

  Grad. Sch. Pharm. Sci. Nagoya City Univ.:okazaki Inst. Integ. Biosci. Natl. Inst. Natl. Sci.

• Akita H

  Toho Univ. Chiba Jpn

• Akita Hiroyuki

  School Of Pharmaceutical Science Toho University

• Takahashi K

  School Of Pharmaceutical Sciences Toho University

• NOZAWA Masako

  School of Pharmaceutical Sciences, Toho University

• Kato Keisuke

  School Of Pharmaceutical Sciences Toho University

• TAKAHASHI Keiko

  School of Pharmaceutical Sciences, Toho University

• Nozawa M

  Graduate School Of Pharmaceutical Sciences Chiba University

• 野澤 雅子

  School Of Pharmaceutical Science Toho University

• Akita Hiroyuki

  School Of Parmaceutical Sciences Toho University

• Kato Keisuke

  School Of Pharmaceutical Science Toho University

• Takahashi Keiko

  School Of Pharmaceutical Sciences Toho University

• Kato Koichi

  Okazaki Institute For Integrative Bioscience Institute For Molecular Science

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