Enantioselective Reaction of (±)-1-Hydroxy-5-methyl-3-vinylcyclohex-2-ene and Its Acyl Derivatives Using Lipid-Lipase Aggregates in Organic Solvent

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概要

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• The enzymatic esterification or hydrolysis of 1-hydroxy((±)-1), 1-acetoxy((±)-2) and 1-butyryloxy-5-methyl-3-vinylcyclohex-2-ene ((±)-3) was carried out using lipid-lipase aggrgates. The esterification of (±)-1 provided (1S, 5S)-1 with >99% ee using lipid-lipase "Amano P" with vinyl butyrate as the acylating reagent.

• 公益社団法人日本薬学会の論文
• 1996-04-15

著者

• Shimizu Noriko

  Kyoritsu University Of Pharmacy

• Shimizu Nobuko

  Pharmaceutical Institute School Of Medicine Keio University

• Akita Hiroyuki

  School Of Parmaceutical Sciences Toho University

• KAWAMATA Takeshi

  Pharmaceutical Institute, School of Medicine, Keio University

• Kawamata T

  Pharmaceutical Institute School Of Medicine Keio University

• Kawamata Takeshi

  Pharmaceutical Institute School Of Medicine Keio University

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