Enzymatic Synthesis of (-)- and (+)-Acetoxyhexamides and (-)- and (+)-Hydroxyhexamides
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概要
- 論文の詳細を見る
The enantioselective hydrolysis of (±)-4-(1-acetoxyethyl)-N-(cyclohexylcarbamoyl)-benzenesulfonamides 3 with lipase Amano P from Pseudomonas sp. in a water-saturated solvent gave (R)-4-(1-hydroxyethyl)-N-(cyclohyxylcarbamoyl)benzenesulfonamide 2 (39%, >99% ee) and unchanged (S)-3 (50%, 62% ee). On the other hand, enantioselective esterification of (±)-2 with lipase Amino P in the presence of vinyl acetate provided (R)-3 (41%, >99% ee) and unchanged (S)-2 (46%, 78% ee).
- 公益社団法人日本薬学会の論文
- 1999-08-15
著者
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AKITA Hiroyuki
School of Pharmaceutical Science, Toho University
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Akita H
Toho Univ. Chiba Jpn
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Akita Hiroyuki
School Of Pharmaceutical Science Toho University
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Imamura Yorishige
Faculty Of Pharmaceutical Sciences Kumamoto University
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NOZAWA Masako
School of Pharmaceutical Sciences, Toho University
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Kurashima Katsumi
Central Research Laboratory Godo Shusei Co. Ltd.
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Nozawa M
Graduate School Of Pharmaceutical Sciences Chiba University
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野澤 雅子
School Of Pharmaceutical Science Toho University
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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KAWANA Takako
School of Pharmaceutical Sciences, Toho University
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HIRAYAMA Kiyomi
School of Pharmaceutical Sciences, Toho University
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SERI Kenji
Central Research Laboratory, Godo Shusei Co., Ltd.,
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Seri Kenji
Central Research Laboratory Godo Shusei Co. Ltd.
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Kawana Takako
School Of Pharmaceutical Sciences Toho University
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Hirayama Kiyomi
School Of Pharmaceutical Sciences Toho University
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