Chemoenzymatic Synthesis of (+)-α-Polypodatetraene and Methyl (5R,10R,13R)-Labda-8-en-15-oate
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概要
- 論文の詳細を見る
The reported enzymatic resolution products {acetate of (1S,4aS,8aS)-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2-ethylene acetal} (8aS)-5 (>99% ee)] and [(1R,4aR,8aR)-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2-ethylene acetal (8aR)-4 (98% ee) were converted to (+)-α-polypodatetraene (1) and methyl (5R,10R,13R)-labda-8-en-15-oate (2), respectively. For the synthesis of (5R,10R,13R)-2, chiral isoprene congener (3S)-26 corresponding to the right part of 2 was synthesized based on the lipase-assisted resolution of (±)-2-methyl-3-(p-methoxyphenyl)propanol (17).
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
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Akita H
Toho Univ. Chiba Jpn
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Miyake Takahiro
School Of Pharmaceutical Sciences Toho University:tsukuba Research Institute Novartis Pharma K.k.
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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Kinoshita Masako
School Of Pharmaceutical Sciences Toho University
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ARIMA Yuusuke
School of Pharmaceutical Sciences, Toho University
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OGUMA Minako
School of Pharmaceutical Sciences, Toho University
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Oguma Minako
School Of Pharmaceutical Sciences Toho University
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Arima Yuusuke
School Of Pharmaceutical Sciences Toho University
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Kinoshita Masako
Fac. Of Pharmaceutical Sciences Toho Univ.
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