Enzymatic Resolution of (±)-5-Acetoxy-4-aryl-(2E)-pentenoate Derivatives

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概要

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• Enzymatic resolution of six (±)-5-acetoxy-4-aryl-(2E)-pentenoate derivatives, compounds 9, 11, 13, 15, 17, and 19 bearing a different aromatic substitution pattern, using lipase OF-360 from Candida rugosa was carried out. The absolute configurations of all hydrolyzed products and all unchanged acetates were found to be S and R, respectively. Moreover, the enantiomeric excess of the enzymatic resolution products from 9, 11, and 13 with the ortho-methoxyl group in the aromatic ring was higher than that of the substrates with no methoxyl group at the ortho-position in the aromatic ring.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• AKITA Hiroyuki

  School of Pharmaceutical Science, Toho University

• Akita H

  Toho Univ. Chiba Jpn

• Akita Hiroyuki

  School Of Pharmaceutical Science Toho University

• ONO Machiko

  School of Pharmaceutical Sciences, Toho University

• Akita Hiroyuki

  School Of Parmaceutical Sciences Toho University

• TANIKAWA Shin

  School of Pharmaceutical Sciences, Toho University

• Tanikawa Shin

  School Of Pharmaceutical Sciences Toho University

• Ono M

  School Of Pharmaceutical Sciences International University Of Health And Welfare

• Ono Machiko

  School Of Pharmaceutical Sciences Toho University

• Ono Machiko

  School Of Pharmaceutical Sciences International Univ. Of Health And Welfare

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