Chemoenzymatic Synthesis of Sacranosides A and B
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概要
- 論文の詳細を見る
Direct β-glucosidation between (-)-myrtenol and nerol and D-glucose (3) using the immobilized β-glucosidase from almonds with the synthetic prepolymer ENTP-4000 gave myrtenyl O-β-D-glucoside (4) and neryl O-β-D-glucoside (10), respectively. The coupling of the myrtenyl or neryl O-β-D-glucopyranoside congeners (7 or 13) and 2,3,4-tri-O-benzoyl-β-L-arabinopyranosyl bromide (8) afforded the coupled products (9 or 14), respectively. Deprotection of the coupled products (9 or 14) afforded the synthetic myrtenyl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside (Sacranoside A, 1) or neryl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside (Sacranoside B, 2), respectively.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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Fujii Mikio
School Of Pharmaceutical Sciences Showa University
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IDA Yoshiteru
School of Pharmaceutical Sciences, Showa University
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AKITA Hiroyuki
School of Pharmaceutical Science, Toho University
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Akita H
Toho Univ. Chiba Jpn
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Akita Hiroyuki
School Of Pharmaceutical Science Toho University
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Ida Yoshiteru
School Of Pharmaceutical Sciences Showa University
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Ida Yoshiteru
Yokohama College Of Pharmacy
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KAWAHARA Eiji
School of Pharmaceutical Sciences, Toho University
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Kawahara Eiji
School Of Pharmaceutical Sciences Toho University:tsukuba Research Institute Novartis Pharma K.k.
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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Ida Yoshiteru
School Of Pharmacy Showa University:yokohama College Of Pharmacy
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