Determination of the Absolute Structure of (+)-Cystothiazole B
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概要
- 論文の詳細を見る
Palladium-catalyzed cyclization-methoxycarbonylation of (2R, 3S)-3-methylpenta-4-yne-1, 2-diol (6) derived from (2R, 3S)-epoxy butanoate 5, followed by methylation, gave the tetrahydro-2-furylidene acetate (-)-7, which was converted to the left-half aldehyde (+)-3. A Wittig reaction between (+)-3 and the phosphoranylide derived from the bithiazole-type phosphonium iodide 4 using lithium bis(trimethylsilyl)amide afforded (+)-cystothiazole B (2), the spectral data of which were identical to those of the natural product (+)-2. Thus the stereochemistry of cystothiazole B (2) was confirmed to be [4R, 5S, 6(E)].
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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Sasaki T
School Of Pharmaceutical Sciences Toho University
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Akita Hiroyuki
School Of Pharmaceutical Sciences Toho University
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Kato Keisuke
School Of Pharmaceutical Sciences Toho University
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Sasaki Takamitsu
School Of Pharmaceutical Sciences Toho University
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Akita Hiroyuki
School Of Parmaceutical Sciences Toho University
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Kato Keisuke
School Of Pharmaceutical Science Toho University
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