Synthetic Study of Piericidins. I. Synthesis of the Side Chain of Piercidin B_1

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概要

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• The side chain of piericidin B_1 having four (E)-olefinic linkages was prepared. The coupling reaction of the non-conjugated aldehyde (22) derived from 4,4-dimethoxy-2-butanone and the sulfone (13) afforded a diastereomeric mixture of the hydroxy sulfone (27). Benzoylation of 27 followed by reductive olefin formation with sodium amalgam gave the desired all-trans-tetraene (29) possessing an (E)-C(5)-C(6) double bond, which was transformed to the alcohol (1) corresponding to the side chain of piericidin B_1.

• 公益社団法人日本薬学会の論文
• 1997-09-15

著者

• Ono Mayumi

  Department Of Pharmaceutical Oncology Graduate School Of Pharmaceutical Sciences Kyushu University

• Ono M

  Departments Of Biochemistry Kyushu University School Of Medicine

• Ono M

  Kyushu Tokai Univ. Kumamoto Jpn

• Sato E

  Department Of Pharmaceutical Science Akita University School Of Medicine

• AKITA Hiroyuki

  School of Pharmaceutical Science, Toho University

• Yoshida Naoko

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• Akita H

  Toho Univ. Chiba Jpn

• Akita Hiroyuki

  School Of Pharmaceutical Science Toho University

• 吉田 直之

  大日本製薬株式会社創薬研究所第一薬理研究部

• Ono M

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• Sato Etsuko

  Department Of Pharmaceutical Science Akita University School Of Medicine

• Yoshida Naotoshi

  Medicinal Plant Garden Faculty Of Pharmaceutical Sciences Hokkaido University

• Ono Masaki

  Analytical Laboratory Self-medication Laboratories Taisho Pharmaceutical Co. Ltd.

• 吉田 直之

  大日本製薬株式会社創薬研究所

• ONO Machiko

  School of Pharmaceutical Sciences, Toho University

• YOSHIDA Norio

  School of Pharmaceutical Sciences, Toho University

• KOKUBU Yuki

  School of Pharmaceutical Sciences, Toho University

• SATO Eiji

  School of Pharmaceutical Sciences, Toho University

• Ono M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Akita Hiroyuki

  School Of Parmaceutical Sciences Toho University

• Ono Machiko

  School Of Pharmaceutical Sciences Toho University

• Kokubu Yuki

  School Of Pharmaceutical Sciences Toho University

• Ono Machiko

  School Of Pharmaceutical Sciences International Univ. Of Health And Welfare

• Kokubo Yuki

  School of Pharmaceutical Sciences, Toho University

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