Synthesis and Gastroprokinetic Activity of 2-Amino-N-[(4-benzyl-2-morpholinyl)methyl]benzamide Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
2-Alkoxy-4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chlorobenzamides had been identified as the interesting members of a series of selective and potent gastroprokinetic agents. A new series of 2-amino- and 2-(substituted amino)-N-[(4-benzyl-2-morpholinyl)methyl]benzamides (13-35) has been synthesized and these compounds were examined to determine whether they have advantages over the 2-morpholinyl benzamides 1 with a 2-alkoxy group.The gastroprokinetic activity was generally reduced, but several compounds showed relatively potent activity, comparable to that of the standard agent, metoclopramide. N-[(4-Benzyl-2-morpholinyl)methyl]-4-chloro-2-[(4-chlorobenzoyl)amino]benzamide (32) showed the most potent activity in this series.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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森江 俊哉
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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吉田 直之
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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賀登 志朗
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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森江 俊哉
大日本製薬株式会社創薬研究所
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吉田 直之
大日本製薬(株)薬理研究所
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Kato Satoru
Kanazawa Univ. Kanazawa Jpn
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賀登 志朗
大日本製薬株式会社創薬研究所
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大野 一教
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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吉田 豊吉
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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成戸 俊介
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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成戸 俊介
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Yoshida Naoko
Institute For Medical And Dental Engineering Tokyo Medical And Dental University
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Naruto Shunsuke
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Kato S
Discovery Research Laboratories I Dainippon Pharmaceutical Co. Ltd.
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Kato S
Chemistry Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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吉田 直之
大日本製薬株式会社創薬研究所第一薬理研究部
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Yoshida Naotoshi
Medicinal Plant Garden Faculty Of Pharmaceutical Sciences Hokkaido University
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吉田 直之
大日本製薬株式会社創薬研究所
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大野 一教
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Ohno K
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Kato Satoru
Department Of Molecular Neurobiology Graduate School Of Medicine University Of Kanazawa
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吉田 豊吉
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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