Synthesis and Some Chemical Transformations of 2-Azidomethylindoles
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概要
- 論文の詳細を見る
Several 3-substituted 2-azidomethylindoles have been synthesized in high yields either by the reaction of 3-substituted 2-alkylindoles with iodine azide in dry acetonitrile or by treatment of 3-substituted 2-alkyl-3-chloroindolenines with sodium azide in acetic acid. 1,3-Dipolar cycloaddition of the 2-azidomethylindoles with dimethyl acetylenedicarboxylate gives 2-triazolylmethylindole derivatives. Ozonolysis of 3-phenyl-2-azidomethylindoles in acetic acid gives 2-azidoacetamidobenzophenones, which cyclize to 1,4-benzodiazepines by treating with triphenylphosphine in toluene at room temperature and then refluxing.
- 社団法人日本薬学会の論文
- 1978-09-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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千 文宇
Faculty of Pharmaceutical Sciences, Osaka University
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権 順度
Faculty of Pharmaceutical Sciences, Osaka University
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池田 正澄
Faculty of Pharmaceutical Sciences, Osaka University
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権 順度
Faculty Of Pharmaceutical Sciences Osaka University
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池田 正澄
Kyoto Pharmaceutical University
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千 文宇
Faculty Of Pharmaceutical Sciences Osaka University
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大野 一教
Faculty of Pharmaceutical Sciences, Osaka University
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大野 一教
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Ohno K
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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