Synthesis of Ethyl Arylacetates by Means of Friedel-Crafts Reaction of Aromatic Compounds with Ethyl α-Chloro-α-(methylthio) acetate
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概要
- 論文の詳細を見る
Friedel-Crafts reaction of aromatic compounds with ethyl α-chloro-α-(methylthio)-acetate (1) gave ethyl α-(methylthio) arylacetates (2), which were readily converted into ethyl arylacetates (3) by reductive desulfurization with Raney nickel or zinc dust-acetic acid. The reactions were applied to the syntheses of ibufenac (5) and alclofenac (6), which are anti-inflammatory agents.
- 社団法人日本薬学会の論文
- 1982-03-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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石橋 弘行
Faculty of Pharmaceutical Sciences, Osaka University
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石橋 弘行
金沢大学薬学部
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石橋 弘行
京都薬科大学
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Choi Hongdae
Faculty Of Pharmaceutical Sciences Osaka University
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新堂 裕久
Faculty of Pharmaceutical Sciences, Osaka University
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新堂 裕久
Faculty Of Pharmaceutical Sciences Osaka University
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