1,3-Dipolar Cycloaddition Reaction of 1-Methylperimidine 3-Ylides with Dimethyl Acetylenedicarboxylate

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概要

• 論文の詳細を見る

• 3-Amino-1-methylperimidinium mesitylenesulfonate reacted with dimethyl acetylene-dicarboxylate (DMAD) in the presence of base to give dimethyl 1-(8-methylamino-1-naphthyl) pyrazole-3,4-dicarboxylate, whereas the reaction of the 2-methyl congener gave dimethyl 7-methyl-7H-benzo [de] pyrazolo [3,2-b] quinazoline-8,9-dicarboxylate as a major product. The reaction of 1-methyl-3-phenacyl-and 3-methoxycarbonylmethyl-perimidinium bromides with DMAD gave dimethyl 1-(8-methylamino-1-naphthyl)-2-benzoyl-pyrrole-3,4-dicarboxylate and trimethyl 1-(8-methylamino-1-naphthyl) pyrrole-2,3,4-tricarboxylate as major products, respectively.

• 公益社団法人日本薬学会の論文
• 1983-04-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 池田 正澄

  Faculty of Pharmaceutical Sciences, Osaka University

• 池田 正澄

  Kyoto Pharmaceutical University

• 壺内 英継

  Microbiological Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 壺内 英継

  Faculty of Pharmaceutical Sciences, Osaka University

• 土井 恵美子

  Faculty Of Pharmaceutical Sciences Osaka University

• 壺内 英継

  Microbiological Research Institute Otsuka Pharmaceutical Co. Ltd.

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