A Novel Oxidative Intramolecular [4+2]Cycloaddition of Silylene-Protected Dihydroxystyrene Derivatives Leading to peri-Hydroxy Polycyclic Aromatic Compounds : A Synthesis of the ABCD Ring System of Frederucamycin A

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概要

• 論文の詳細を見る

• Heating of the silylene protected dihydroxystyrene generated from the O-hydroxyacetophenone (3a) at 130-150℃ for 15-48h in a sealed tube gave intramolecular [4+2]cycloaddition products (5 and 6). The addition of chloranil to the reaction mixture brought about an oxidative intramolecular [4+2]cycloaddition to give the linearly condensed peri-hydroxy aromatic compound(7a) in excellent yield. The generality of this cycloaddition and application to a short and efficient synthesis of the ABCD ring system of fredericamycin A are described.

• 社団法人日本薬学会の論文
• 1991-08-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty of Pharmaceutical Sciences, Osaka University

• 北 泰行

  大阪大学大学院薬学研究科

• 北 泰行

  大阪大学薬学部

• 近藤 麻衣子

  Faculty Of Pharmaceutical Sciences Osaka University

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka

• 奥仲 隆一

  Faculty of Pharmaceutical Sciences, Osaka University

• 本田 孝雄

  Faculty of Pharmaceutical Sciences, Osaka University

• 田村 修

  Faculty of Pharmaceutical Sciences, Osaka University

• 田村 修

  Faculty Of Pharmaceutical Sciences Osaka University

• 田村 修

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 本田 孝雄

  Faculty Of Pharmaceutical Sciences Osaka University

• 奥仲 隆一

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty Of Pharmaceutical Sciences Osaka University

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