5-Hydroxy-and Methoxy-1-(tert-aminoalkyl)-3,4-dihydrocarbostyrilの合成
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概要
- 論文の詳細を見る
5-Hydroxy-1-(tert-aminoalkyl)-3,4-dihydrocarbostyrils (Va-f) and their methyl ethers (IVa-f) were prepared for evaluation of their pharmacological activities. Alkylation of 5-methoxy-3,4-dihydrocarbostyril (III) with the tert-aminoalkyl chlorides in refluxing xylene in the presence of sodium hydride gave 5-methoxy-1-(tert-aminoalkyl)-3,4-dihydrocarbostyrils (IVa-f) in 52-92% yields. Demethylation of IVa-f with 48% hydrobromic acid gave Va-f in 81-88% yields. The results are summarized in a Chart and Tables.
- 公益社団法人日本薬学会の論文
- 1972-06-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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田村 恭光
大阪大学薬学部
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尾崎 和成
大阪大学薬学部
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小山 健一
大阪大学薬学部
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須本 国弘
大阪大学薬学部
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