Synthesis and Stereochemistry in B/C Ring Juncture of Lactamcarbinol A, a Degradation Product of Securinine

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概要

• 論文の詳細を見る

• Cis-and trans-2-Hydroxy-2-(2-pyridyl) cyclohexaneacetic acid, (X) and (VIII), were synthesized and their stereochemistries discussed. The latter (VIII) was converted into racemic lactam-carbinol A (I), which showed the same infrared spectrum in chloroform as that of natural lactam-carbinol A obtained by degradation of securinine. The present work proved unequivocally the stereochemistries in B/C ring junctures of lactamcarbinols A (I) and B (II), and quinolizidines A (IV) and B (V), degradation products of securinine.

• 社団法人日本薬学会の論文
• 1965-01-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Josai University

• 吉川 浩

  Faculty Of Pharmaceutical Sciences Osaku University

• 花岡 美代次

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 斉藤 清一

  田辺製薬研

• 斎藤 清一

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 斎藤 清一

  Osaka Research Laboratory, Gohei Tanabe & Co., Ltd.

• 山脇 泰彦

  Faculty of Pharmaceutical Sciences, Osaka University

• 吉川 浩

  Osaka Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 堀井 善一

  Faculty Of Pharmaceutical Sciences Osaka University

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