Asymmetric Synthesis Using Chiral Acetals : Studies on the Nucleophilic Addition of Organometaltics to Chiral α-Keto Acetals in Cyclic Systems(Organic,Chemical)

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概要

• 論文の詳細を見る

• Four chiral cyclic α-keto acetals (3a-d) were prepared through transacetalization of the α-hydroxydimethyl acetals [1(n=1, n=2)] with (-)-(2S,,3S)-1,4-diniethoxy-2,3-butanediol or (-)-(2R,3R)-2,3-butanediol and reacted with organometallic reagents (Grignard reagents and organolithium reagents). The reactions of the α-keto acetals (3a, 3b) derived from 1 and (-)-(2S,3S)-1,4-dimethoxy-2.3-butanediol with Gricnard reagents proceeded in a highly diastereoselective manner.

• 社団法人日本薬学会の論文
• 1987-06-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨士 雅弘

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 藤岡 弘道

  大阪大学大学院薬学研究科

• 藤岡 弘道

  Faculty Of Pharmaceutical Sciences Osaka University

• 案浦 洋一

  Faculty of Pharmaceutical Sciences, Osaka University

• 近藤 洋司

  Faculty of Pharmaceutical Sciences, Osaka University

• 冨士 雅弘

  Faculty of Pharmaceutical Sciences, Osaka University

• 吉田 孝行

  Faculty of Pharmaceutical Sciences, Osaka University

• 近藤 洋司

  Faculty Of Pharmaceutical Sciences Osaka University

• 吉田 孝行

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 案浦 洋一

  Faculty Of Pharmaceutical Sciences Osaka University

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