Synthetic Anthracyclines : Regiospecific Total Synthesis of a D-Ring Indole Analogue of Daunomycin

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概要

• 論文の詳細を見る

• The 4-methoxy-5-methylpyrano[3,4,-b]indole-1,3(4H, 5H)-dione (9), prepared from methyl 3-methoxycarbonyl-1-methylindol-2-yl acetate (6), underwent a strong base-induced cycloaddition reaction with 2-chloro-6,6-ehylenedioxy-5,6,7,8-tetrahydro-1,4-naphtoquinone (11) to give the tetrahydronaphtho[2,3-b]carbazole-7,12-dione (10), regioselectively. The cycloadduct (10) was successfully converted to a D-ring indole analogue of daunomycin (1a).

• 社団法人日本薬学会の論文
• 1990-03-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 桐原 正之

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty of Pharmaceutical Sciences, Osaka University

• 北 泰行

  大阪大学大学院薬学研究科

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka

• 藤井 裕士

  Faculty of Pharmaceutical Sciences, Osaka University

• 奥仲 隆一

  Faculty of Pharmaceutical Sciences, Osaka University

• 下岡 釿雄

  New Product Development Center, Pfizer Pharmaceutical Inc., Ltd.,

• 堰八 淳一

  Faculty of Pharmaceutical Sciences, Osaka University

• 佐生 学

  Faculty of Pharmaceutical Sciences, Osaka University

• 堰八 淳一

  Faculty Of Pharmaceutical Sciences Osaka University

• 藤井 裕士

  Faculty Of Pharmaceutical Sciences Osaka University

• 佐生 学

  Faculty Of Pharmaceutical Sciences Osaka University

• 奥仲 隆一

  Faculty Of Pharmaceutical Sciences Osaka University

• 下岡 釿雄

  New Product Development Center Pfizer Pharmaceutical Inc. Ltd.

• 北 泰行

  Faculty Of Pharmaceutical Sciences Osaka University

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