Total Synthesis of 11-Deoxyanthracyclines : 4-Demethoxy-11-deoxy-daunomycin : 11-Deoxydaunomycin, and Their Analogues
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概要
- 論文の詳細を見る
Practical total synthesis of 11-deoxyanthracyclinones (8 and 9) was accomplished on the basis of two effective syntheses of the key intermediates (14 and 15) and the subsequent highlystereoselective introduction of a C-7 cis-hydroxyl group. Glycosidation of 8 with a suitably protected L-daunosamine (37) followed by deprotection provided 4-demethoxy-11-deoxydaunomycin (5). The C-13 acetal derivative (34) of 9 was successfully employed for the glycosidation to acehieve the first total synthesis of 11-deoxydaunomycin (6). Two novel synthetic 11-deoxy-anthracyclines (10 and 11) possessing a neutral sugar instead of L-daunosamine were also synthesized.
- 社団法人日本薬学会の論文
- 1988-10-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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桐原 正之
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
大阪大学大学院薬学研究科
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赤井 周司
大阪大学大学院薬学研究科
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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赤井 周司
Faculty of Pharmaceutical Sciences, Osaka University
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佐生 学
Faculty of Pharmaceutical Sciences, Osaka University
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岸本 久和
Faculty of Pharmaceutical Sciences, Osaka University
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佐生 学
Faculty Of Pharmaceutical Sciences Osaka University
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岸本 久和
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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