An Efficient, Regiospecific Synthesis of 4-Demethoxydaunomycinone and Daunomycinone(Organic,Chemical)

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概要

• 論文の詳細を見る

• 4-Methoxy and 4-acetoxyhomophthalic anhydrides were prepared by convenient oxidations of homophthalic acid derivatives followed by hydrolysis and dehydrative cyclization. Strong base-induced cycloaddition of these anhydrides to 2-chloro-6, 6-ethylenedioxy-5, 6, 7, 8-tetrahydro-1, 4-naphthoquinone gave the tetracyclic adducts, which were efficiently converted into 4-demethoxydaunomycinone and daunomycinone.

• 社団法人日本薬学会の論文
• 1987-04-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty of Pharmaceutical Sciences, Osaka University

• 北 泰行

  大阪大学大学院薬学研究科

• 赤井 周司

  大阪大学大学院薬学研究科

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka

• 赤井 周司

  Faculty of Pharmaceutical Sciences, Osaka University

• 堰八 淳一

  Faculty of Pharmaceutical Sciences, Osaka University

• 佐生 学

  Faculty of Pharmaceutical Sciences, Osaka University

• 岸本 久和

  Faculty of Pharmaceutical Sciences, Osaka University

• 堰八 淳一

  Faculty Of Pharmaceutical Sciences Osaka University

• 佐生 学

  Faculty Of Pharmaceutical Sciences Osaka University

• 岸本 久和

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty Of Pharmaceutical Sciences Osaka University

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