Synthetic Studies on η-Pyrromycinone. III. Intramolecular Cyclization of methyl 2-Ethyl-5-hydroxy-6-(2-carboxy-3,6-dimethoxybenzoyl)-1-naphthoate
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概要
- 論文の詳細を見る
The Friedel-Crafts condensation of 3,6-dimethoxyphthalic anhydride (II) with methyl 2-ethyl-5-hydroxy-1-naphthoate (III) gave 2-ethyl-5-hydroxy-6-(2-carboxy-3,6-dimethoxy-benzoyl)-1-naphthoate (IV), a key intermediate for the synthesis of η-pyrromycinone (I, R=H). An attempt to cyclize IV to η-pyrromycinone dimethyl ether (I, R=CH_3), however, resulted in formation of 9-ethyl-1,6-dihydroxy-4-methoxynaphthacenequinone (V). The Structure of V was confirmed by alternative synthesis.
- 公益社団法人日本薬学会の論文
- 1965-06-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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堀井 善一
Faculty Of Pharmaceutical Sciences Josai University
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百瀬 雄章
Faculty of Pharmaceutical Sciences, Kinki University
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堀井 善一
Faculty Of Pharmaceutical Sciences Osaka University
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百瀬 雄章
Faculty Of Pharmaceutical Sciences Kanazawa University
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