Strong Base-Induced Cycloaddition Reaction of Homophthalic Anhydride with Aldehydes
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概要
- 論文の詳細を見る
The reaction of homophthalic anhydride (1) and aldehydes in the presence of a strong base was studied. Reaction of 1 and benzaldehyde in the presence of NaH in anhydrous tetrahydrofuran (THF) at low temperature (0℃-room temperature) followed by treatment with diazomethane gave the cycloadduct, trans-4-methoxycarbonyl-3-phenyl-3,4-dihydrocoumarin, and the reaction at 50℃ gave, after similar work-up, the C-4 methylene condensed product, methyl 2-(2-methoxycarbonylphenyl)-3-phenylacrylate, selectively. Treatment of homophthalic anhydride having a terminal aldehyde group in the side chain at the C-4 position with NaH in anhydrous THF at low temperature resulted in intramolecular cycloaddition in fair yield.
- 社団法人日本薬学会の論文
- 1991-05-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
大阪大学大学院薬学研究科
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北 泰行
大阪大学薬学部
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近藤 麻衣子
Faculty Of Pharmaceutical Sciences Osaka University
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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奥仲 隆一
Faculty of Pharmaceutical Sciences, Osaka University
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本田 孝雄
Faculty of Pharmaceutical Sciences, Osaka University
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本田 孝雄
Faculty Of Pharmaceutical Sciences Osaka University
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奥仲 隆一
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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