Synthesis of 2-(Heteroarylthiomethyl)-1β-methylcarbapenem via Propargylation of 4-Acetoxy-2-azetidinone with 3-Methyl-1-tributylstannylallene
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概要
- 論文の詳細を見る
The key intermediate in the synthesis of 1β-methylcarbapenem, (3S, 4R)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1S)-1-methyl-2-propynyl]-2-azetidinone (5β), was prepared by propargylation of (3R, 4R)-4-acetoxy-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3) with 3-methyl-1-tributylstannylallene (4) in the presence of a Lewis acid and successfully converted to a novel 2-(heteroarylthiomethyl)-1β-methylcarbapenem (2).
- 社団法人日本薬学会の論文
- 1989-09-25
著者
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西 耕一
Faculty Of Pharmaceutical Sciences Osaka University
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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春田 純一
Faculty Of Pharmaceutical Sciences Osaka University
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菊池 和美
Faculty of Pharmaceutical Sciences, Osaka University
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松田 聡
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
大阪大学大学院薬学研究科
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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菊池 和美
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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松田 聡
Faculty Of Pharmaceutical Sciences Osaka University
関連論文
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