Monomethylation of Aromatic Rings by Friedel-Crafts Reaction with Chloromethyl Sulfide

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概要

• 論文の詳細を見る

• A novel method for the introduction of a methyl group into aromatic rings in described. Friedel-Crafts reactions of ethyl α-(chloromethylthio)acetate (3k) and α-chloromethylthio-γ-butyrolactone (3m) with an arene in the presence of stannic chloride gave ethyl α-(arylmethylthio)-acetate (6) and α-arylmethylthio-γ-butyrolactone (7), respectively, which were easily converted to the corresponding methylated arene (8) by reductive desulfurization with Raney nickel or zinc dust-acetic acid.

• 公益社団法人日本薬学会の論文
• 1986-02-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 冨士 雅弘

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 石橋 弘行

  Kyoto Pharmaceutical University

• 案浦 洋一

  Faculty of Pharmaceutical Sciences, Osaka University

• 冨士 雅弘

  Faculty of Pharmaceutical Sciences, Osaka University

• 石橋 弘行

  金沢大学薬学部

• 石橋 弘行

  京都薬科大学

• 大倉 雅美

  Faculty of Pharmaceutical Sciences, Osaka University

• 大倉 雅美

  Faculty Of Pharmaceutical Sciences Osaka University

• 案浦 洋一

  Faculty Of Pharmaceutical Sciences Osaka University

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