Chemistry of O-Silylated Ketene Acetals : Preparation of α-Siloxy Phenyl Sulfides and Methyl 3-(Phenylthio) butyrates from Alkyl Phenyl Sulfoxides
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概要
- 論文の詳細を見る
Treatment of alkyl phenyl sulfoxides (2a-h) with O-methyl-O-tert-butyldimethylsily ketene acetal (1a) in dry acetonitrile in the presence of a catalytic amount of zinc iodide caused a Pummerer-type rearrangement to give α-siloxy phenyl sulfides (3a-h) under mild conditions. On the other hand, treatment of the sulfoxide (2d) with O-methyl-O-trimethylsilyl ketene acetals (1b, c) under similar conditions gave carbon-carbon bond-formed products, methyl 3-(phenylthio)-butyrates (8 and 9).
- 公益社団法人日本薬学会の論文
- 1985-10-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
大阪大学大学院薬学研究科
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安田 均
Faculty Of Pharmaceutical Sciences Osaka University
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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田村 修
Faculty of Pharmaceutical Sciences, Osaka University
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伊藤 文雄
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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伊藤 文雄
Faculty of Pharmaceutical Sciences, Osaka University
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田村 修
Faculty Of Pharmaceutical Sciences Osaka University
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田村 修
Faculty Of Pharmaceutical Sciences Kanazawa University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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