Synthetic Anthracyclines : Total Synthesis of D-Ring Pyridine and Pyrazine Analogues of 11-Deoxydaunomycin

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概要

• 論文の詳細を見る

• Treatment of sodium salts generated from tetrahydrohomophthalic anhydrides (6a, b) with 5,8-dihydro-5,8-dioxoquinoline (9) gave cycloadducts (7 and 8), regioselectively. These adducts were converted to the D-ring pyridine analogue (21) of 11-deoxydaunomycin. The D-ring pyrazine analogue (27) of 11-deoxydaunomycin was also prepared by a similar method.

• 社団法人日本薬学会の論文
• 1991-04-25

著者

• 田村 恭光

  Faculty Of Pharmaceutical Sciences Osaka University

• 大石 宏文

  Osaka University of Pharmaceutical Sciences

• 石田 寿昌

  Osaka University of Pharmaceutical Sciences

• 桐原 正之

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty of Pharmaceutical Sciences, Osaka University

• 北 泰行

  大阪大学大学院薬学研究科

• 赤井 周司

  大阪大学大学院薬学研究科

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka

• 前田 ひろし

  Faculty of Pharmaceutical Sciences, Osaka University

• 赤井 周司

  Faculty of Pharmaceutical Sciences, Osaka University

• 藤井 裕士

  Faculty of Pharmaceutical Sciences, Osaka University

• 奥仲 隆一

  Faculty of Pharmaceutical Sciences, Osaka University

• 下岡 釿雄

  New Product Development Center, Pfizer Pharmaceutical Inc., Ltd.,

• 藤井 裕士

  Faculty Of Pharmaceutical Sciences Osaka University

• 奥仲 隆一

  Faculty Of Pharmaceutical Sciences Osaka University

• 下岡 釿雄

  New Product Development Center Pfizer Pharmaceutical Inc. Ltd.

• 前田 ひろし

  Faculty Of Pharmaceutical Sciences Osaka University

• 北 泰行

  Faculty Of Pharmaceutical Sciences Osaka University

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