Nonsteroidal Antiinflammatory Agents. III. : Synthesis of the Metabolites of 10,11-Dihydro-8,α-dimethyl-11-oxodibenz[b, f]oxepin-2-acetic Acid (Bermoprofen)

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概要

• 論文の詳細を見る

• The metabolites (3 and 4) of 10,11-dihydro-8,α-dimethyl-11-oxodibenz[b, f]oxepin-2-acetic acid (bermoprofen, AD-1590,1), a promising antiinflammatory drug, were synthesized to confirm the proposed structures, and all the metabolites (2-4) were tested for activity in the carrageenin-induced edema test in rats. Metabolites 2 and 3 showed slight inhibition but 4 had no effect after intravenous administration.

• 社団法人日本薬学会の論文
• 1988-09-25

著者

• 賀登 志朗

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 中村 秀雄

  Dainippon Pharmaceutical Co., Ltd.,

• 中村 秀雄

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 永井 保嵩

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 賀登 志朗

  大日本製薬株式会社創薬研究所

• 日野 克彦

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 入江 明

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 宇野 準

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 入江 明

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• Kato S

  Discovery Research Laboratories I Dainippon Pharmaceutical Co. Ltd.

• 日野 克彦

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  大日本製薬株式会社

• 中村 秀雄

  Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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