Studies on Psychotropic Agents. IV. Alkylation of 2-Substituted 2,3,4,5-Tetrahydro-1H-pyrido [4,3-b] indole Derivatives
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概要
- 論文の詳細を見る
The alkylation of 2-substituted 2,3,4,5-tetrahydro-1H-pyrido [4,3-b] indoles (1) with sodium amide and alkyl halide in non-polar solvents proceeded most smoothly when the substituent in the 2 position was a benzyl group, and gave 5-alkyl-1,2,3,4-tetrahydropyrimido [1,6-a] indoles (2) and 5-alkyl-tetrahydropyrido [4,3-b] indoles (3). The ratio of 2 to 3 depended on the halide employed. The tetrahydropyrimido [1,6-a] indole derivatives (5) with a 3-(p-fluorobenzoyl) propyl group in the 2 position were also prepared.
- 公益社団法人日本薬学会の論文
- 1979-08-25
著者
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永井 保嵩
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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入江 明
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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入江 明
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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南 新作
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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宇野 準
大日本製薬株式会社
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南 新作
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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