Studies on Psychotropic Agents. II. Synthesis of 1-Substituted-3-(p-fluorophenacyl) piperidines and the Related Compounds
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概要
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A series of 1-substituted-3-phenacylpiperidine derivatives (VI) and 1-substituted-3-(p-fluorophenacyl) pyrrolidine derivatives (XI) were synthesized for pharmacological testing. The conversion of 3-phenacyl-4-piperidone derivatives (XXII) into 4,5,6,7-tetrahydrofuro (or-1H-pyrrolo) [3,2-c] pyridine derivatives (XX, XXV), the rearrangement of the quaternary salts of these products (XXa, XXVb) with phenyllithium and the dimerization of the dehydration product of 1-benzyl-3-hydroxymethyl-4-piperidone (K) were also described. Among the compounds synthesized, 1-(p-fluorobenzoyl) propyl-3-(p-fluorophenacyl)-pyrrolidine (XId) showed remarkable central nervous system depressing activities.
- 公益社団法人日本薬学会の論文
- 1977-08-25
著者
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永井 保嵩
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社
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梅本 進
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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梅本 進
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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