4-Phenyl-2-(1-piperazinyl)quinolines with Potent Antidepressant Activity
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概要
- 論文の詳細を見る
A series of 2-amino-4-phenylquinolines was synthesized and the effects of these compounds on the central nervous system were evaluated pharmacologically in mice. Among these compounds, many 2-(substituted piperazinyl) derivatives exhibited a potent antagonism to hypothermia and catalepsy induced by reserpine, as well as some inhibitory effect on locomotor activity. Some compounds were found to possess activity to inhibit tremorine-induced tremor.
- 公益社団法人日本薬学会の論文
- 1980-09-25
著者
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永井 保嵩
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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日野 克彦
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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日野 克彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
大日本製薬株式会社
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古川 清
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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