Synthesis and Antiallergic Activity of N-[4-(4-Diphenylmethyl-1-piperazinyl)butyl]-1,4-dihydro-4-oxopyridine-3-carboxamides
スポンサーリンク
概要
- 論文の詳細を見る
A new series of oxopyridinecarboxamide derivatives 3a-g and 5a were synthesized and evaluated for their antiallergic activity. 1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamides 3a and 5a exhibited potent antiallergic activity (inhibitory rates of 80.7 and 88.3%, respectively, at 20mg/kg, p.o.) in the rat passive cutaneous anaphylaxis (PCA) test and also exhibited much more potent in vitro inhibitory activity than caffeic acid against the enzyme 5-lipoxygenase (5-LO). Their in vitro antihistamine activity, however, was weaker than that of ketotifen. Compounds 3a and 5a are viewed as promising candidates for antiallergic agents.
- 公益社団法人日本薬学会の論文
- 1989-05-25
著者
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松本 純一
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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松本 純一
Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.
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中村 秀雄
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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松本 純一
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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石井 勝美
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
大日本製薬株式会社総合研究所
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西川 義則
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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新藤 徳彦
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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近 達也
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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宇野 準
大日本製薬株式会社
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近 達也
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
大日本製薬
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宇野 準
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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松本 純一
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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西川 義則
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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新藤 徳彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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