Sythesis and Stereochemistry of 11-Amino-6,6a, 7,8,9,10,10a, 11-octahydrodibenzo[b, e]thiepines and-oxepines

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概要

• 論文の詳細を見る

• 11-Amino-6,6a, 7,8,9,10,10a, 11-octahydrodibebenzo[b, e]thiepines (6a-d) and -oxepines (7a-d) were synthesized by the Leuckart reaction of 6,6a, 7,8,9,10,10a, 11-octahydro-11-oxodibenzo[b, e]thiepines (1a, b)and -oxepines (2a, b) followed by hydrolysis of the reaction products 4a-d and 5a-d, respectively. The four diastereomers, cis(6a-H, 10a-H)-cis(10a-H, 11-H) 6a and 7a, cis(6a-H, 10a-H)-trans(10a-H, 11-H) 6b and 7b, trans(6a-H, 10a-H)-trans(10a-H, 11a-H)6c and 7c, and trans(6a-H, 10a-H)-cis(10a-H, 11-H) 6d and 7d, were isolated and their configurations and conformations were elucidated by chemical methods together with ^1H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

• 公益社団法人日本薬学会の論文
• 1992-09-25

著者

• 松本 純一

  Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 黒川 美貴雄

  Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 糸川 彰

  Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 福本 吉久

  Faculty of Engineering, Tottori University

• 月原 冨武

  Faculty of Engineering, The University of Tokushima

• 月原 冨武

  Faculty Of Engineering The University Of Tokushima

• 黒川 美貴雄

  大日本製薬株式会社創薬研究所

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 糸川 彰

  Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 福本 吉久

  Faculty Of Engineering Tottori University

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