A New Synthesis of 7H-Pyrido[1,2,3-de][1,4]benzoxazine Derivatives Including an Antibacterial Agent, Ofloxacin

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概要

• 論文の詳細を見る

• A new method for the synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2,3,4,5-tetrafluoro-benzoylacetate. As an application of this method, ofloxacin, an antibacterial agent, was synthesized.

• 公益社団法人日本薬学会の論文
• 1986-10-25

著者

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 松本 純一

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 江川 宏

  Exploratory Research Laboratories, Dainippon Pharmaceutical Company, Ltd.,

• 宮本 皓之

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 江川 宏

  Research Laboratories Dainippon Pharmaceutical Co., Ltd.,

• 江川 宏

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 宮本 皓之

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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