Ampicillin及びAmoxicillin誘導体の研究(第2報)Sodium 6-[D-2-(2-(4-Formyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxamido)-p-hydroxyphenylacetamido]penicillanate(PL-385)の分解物の構造

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概要

• 論文の詳細を見る

• A mode of the alkaline and acidic degradation of sodium 6-[D-2-(2-(4-formyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido [2,3-d] pyrimidine-6-carboxamido)-p-hydroxyphenylacetamido] penicillanate (1,PL-385) and structures of the degradation products were studied. Treatment of 1 with three equimolar amounts of sodium hydroxide produced a kinetically stable intermediate, (5R)-penicilloic acid (2a), which on kept at 37℃ for 65h was converted into a thermodynamically stable product, (5S)-penicilloic acid (2b). Treatment of 1 with an excess of sodium hydroxide gave a deformyl derivative (3) arising from the elimination of formly group via 2. On the acidic treatment of 1,the degradation product, (5R, S)-penilloic acid (4), was yielded.

• 公益社団法人日本薬学会の論文
• 1987-08-25

著者

• 廣瀬 徹

  大日本製薬株式会社 総合研究所

• 広瀬 徹

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 松本 純一

  大日本製薬株式会社 総合研究所

• 松本 純一

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 三塩 晋作

  大日本製薬株式会社 総合研究所

• 中野 純次

  大日本製薬株式会社 総合研究所

• 中野 純次

  Exploratory Research Laboratories, Dainippon Pharmaceutical Company, Ltd.,

• 松本 純一

  大日本製薬 総研

• 中野 純次

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 中野 純次

  大日本製薬株式会社総合研究所

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