Pyrido [2,3-d] pyrimidine Antibacterial Agents. II. Piromidic Acid and Related Compounds

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概要

• 論文の詳細を見る

• A series of 8-alkyl-2-amino (or substituted-amino)-5,8-dihydro-5-oxopyrido [2,3-d]-pyrimidine-6-carboxylic acids and related compounds were synthesized and evaluated as antibacterial agents. The most active compounds in vitro against Escherichia coli and Staphylococcus aureus were 8-ethyl-5,8-dihydro-2-dimethylamino-5-oxopyrido [2,3-d]-pyrimidine-6-carboxylic acid (VIIa) and 8-ethyl-5,8-dihydro-5-oxo-2-pyrrolidinopyrido-[2,3-d] pyrimidine-6-carboxylic acid, piromidic acid, (VIIb). Structure-activity relationships are discussed.

• 公益社団法人日本薬学会の論文
• 1971-07-25

著者

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 松本 純一

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 南 新作

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 正野 敬弘

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 南 新作

  大日本製薬株式会社 総合研究所(現):帝国化学産業株式会社研究所

• 正野 敬弘

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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