Studies on Nitrofuran Derivatives. IV. Synthesis of 2- or 4-[2-(5-Nitro-2-furyl) vinyl] pyrimidine Derivatives
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概要
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To test the antibacterial activity, 2- or 4-[2-(5-nitro-2-furyl) vinyl] pyrimidines were synthesized by the condensation of 5-nitro-2-furaldehyde (Va) with the active methyl group of pyrimidines. It has been found that Va predominantly condensed with the 4-methyl group of 2,4-dimethylpyrimidine and in the reaction of Va with 2,4-dimethylpyrimidine containing a functional group in the 6-position, the active hydrogen reactivity between the 2-methyl group and 4-methyl group is affected by the presence of group in the 6-position : in 2,4-dimethylpyrimidines substituted by the hydroxy, amino and alkoxy group in the 6-position, the 2-methyl group was founded to be more active, while in the ones substituted by the acetamido, dimethylamino and chloro group, the 4-methyl group was more reactive.
- 公益社団法人日本薬学会の論文
- 1965-10-25
著者
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高松 秀二
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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南 新作
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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藤田 昭夫
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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藤田 昭夫
大日本製薬株式会社
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南 新作
大日本製薬株式会社
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高松 秀二
大日本製薬株式会社
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山本 格次
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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高松 秀二
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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山本 格次
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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