Studies on Psychotropic Agents. VI. Synthesis of 1'-Methylspiro [6-fluoroindan-1,3'-pyrrolidine]-3-one and Related Compounds

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概要

• 論文の詳細を見る

• The title compounds (19) were synthesized by rearrangement of the 1-ethoxycarbonyl-4-aryl-3,4-epoxypiperidines (7) to give the 3-aryl-3-formylpyrrolidine derivatives (12) for pharmacological testing. Compound (19b) exhibited moderate central nervous system depressing activity. The mechanism of the rearrangement of 1-substituted 4-aryl-3,4-epoxypiperidine with boron trifluoride etherate is discussed.

• 公益社団法人日本薬学会の論文
• 1980-05-25

著者

• 永井 保嵩

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 日野 克彦

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 宇野 準

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,

• 南 新作

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 日野 克彦

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  大日本製薬株式会社

• 南 新作

  Research Laboratory Dainippon Pharmaceutical Co. Ltd.

• 宇野 準

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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