Pyridonecarboxylic Acids as Antibacterial Agents. V. Synthesis of 1-Vinyl-1,4-dihydro-4-oxo-1,8- and 1,6-naphthyridine-3-carboxylic Acids

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概要

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• A series of 7-substituted 1,4-dihydro-4-oxo-1-vinyl-1,8- and 1,6-naphthyridine-3-carboxylic acids (5a-e and 13a-c) was prepared. During the preparation of 5a, unexpected compounds (4,7 and 8) were also obtained. Structural elucidation of these compounds was achieved on the basis of chemical and spectral (ultraviolet, mass and proton nuclear magnetic resonance) data. The structure-antibacterial activity relationships are discussed.

• 公益社団法人日本薬学会の論文
• 1985-10-25

著者

• 廣瀬 徹

  大日本製薬株式会社 総合研究所

• 広瀬 徹

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 松本 純一

  Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.

• 松本 純一

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 廣瀬 徹

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

• 三塩 晋作

  大日本製薬株式会社 総合研究所

• 三塩 晋作

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 南田 明

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 南 新作

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 南 新作

  大日本製薬株式会社 総合研究所(現):帝国化学産業株式会社研究所

• 南田 明

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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