Synthesis and Biological Activity of 11-[4-(Cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b, e]oxepin Derivatives, Potential Agents for the Treatment of Cerebrovascular Disorders
スポンサーリンク
概要
- 論文の詳細を見る
A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b, e]oxepins and related compounds were synthesized and evaluated for their protective activities against complete ischemia, normobaric hypoxia, lipidperoxidation and convulsion. Structure-activity relationship studies of this series led to the finding of (E)-1-(3-fluoro-6,11-dihydrodibenz[b, e]oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate (50), AJ-3941 with the most appropriate property for combined pharmacological activities.
- 公益社団法人日本薬学会の論文
- 1991-10-25
著者
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佐藤 文憲
大日本製薬
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藤原 厳
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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松本 純一
Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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松本 純一
Exploratory Research Laboratories Dainippon Pharmaceutical Company Ltd.
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松本 純一
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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成戸 俊介
Research Laboratories Dainippon Pharmaceutical Co. Ltd
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成戸 俊介
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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吉田 孝行
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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宇野 準
大日本製薬株式会社総合研究所
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黒川 美貴雄
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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佐藤 文憲
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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増田 義信
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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越智 裕子
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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図師 香代子
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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藤原 厳
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
-
宇野 準
大日本製薬株式会社
-
宇野 準
大日本製薬
-
宇野 準
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
-
佐藤 文憲
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
黒川 美貴雄
大日本製薬株式会社創薬研究所
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松本 純一
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
越智 裕子
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
宇野 準
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
藤原 厳
Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
-
図師 香代子
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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