Studies on 3-Substituted 1,2-Benzisoxazole Derivatives. V. Electrophilic Substitutions of 1,2-Benzisoxazole-3-acetic Acid

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概要

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• The site of the electrophilic substitution of 1,2-benzisoxazole-3-acetic acid (1) altered depending on species of electrophiles and reaction conditions. In halogenation, only the α-methylene group of 1 was substituted. In the chlorosulfonation, the α-methylene group was substituted at first and then the 5-position of the nucleus was substituted. On the other hand, in the nitration, the 5-position was substituted at first and the α-methylene group was substituted secondly.

• 公益社団法人日本薬学会の論文
• 1978-11-25

著者

• 宇野 準

  大日本製薬株式会社総合研究所

• 黒川 美貴雄

  Research Laboratories, Dainippon Pharmaceutical Co., Ltd.

• 宇野 準

  大日本製薬株式会社

• 宇野 準

  大日本製薬

• 宇野 準

  Research Laboratory Dainippon Pharmaceutical Co. Ltd.

• 黒川 美貴雄

  大日本製薬株式会社創薬研究所

• 宇野 準

  Research Laboratories Dainippon Pharmaceutical Co. Ltd.

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