A Novel Synthesis of Steroidal [2,3-c] thiophenes
スポンサーリンク
概要
- 論文の詳細を見る
Steroids with a thiophene ring fused to the 2,3 positions were synthesized. Condensation of 2-methoxymethylene-3-ketosteroids (Ia, Ib) with ethyl thioglycolate in the presence of sodium methoxide yielded the tetrahydrothiophene derivatives (Va, Vb), which were dehydrated to the corresponding androstano [2,3-c] thiophene carboxylates (VIa, VIb) by treatment of acids. Hydrolysis, followed by decarboxylation of the carbethoxythiophenes gave the corresponding androstano [2,3-c] thiophenes (Xa, Xb). Similarly androst-4-eno [2,3-c] thiophenes and androstanc [16,17-c] thiophenes were prepared.
- 公益社団法人日本薬学会の論文
- 1968-07-25
著者
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金子 秀彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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黒川 美貴雄
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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大和 譲
大日本製薬株式会社総合研究所
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黒川 美貴雄
大日本製薬株式会社総合研究所
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大和 譲
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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