The Synthesis of 2-and 4-Alkoxymethylestrogens.
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概要
- 論文の詳細を見る
2-Dimethylaminomethylestrone (Ia) and the 4-isomer (IIa) were obtained from the Mannich product of estrone. Methiodides of I'a-c and II'a-c were treated with alcoholic alkali to give 2-and 4-alkoxymethylestrogens in good yields. Methylation in the usual manner of I and II failed, but reaction of I and II with dimethylsulfate in a boiling methanolic alkali gave the 3-methyl ethers of 2-and 4-methoxymethylestrogens, respectively. The structural assignments of the isomers were discussed based on nuclear magnetic resonance, infrared and ultraviolet spectra.
- 公益社団法人日本薬学会の論文
- 1964-02-25
著者
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金子 秀彦
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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金子 秀彦
Research Laboratory Dainippon Pharmaceutical Co. Ltd.
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橋本 昌久
大日本製薬株式会社総合研究所
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小林 昭雄
Faculty of Agriculture, Okayama University
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橋本 昌久
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.,
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小林 昭雄
Faculty Of Agriculture Okayama University
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小林 昭雄
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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橋本 昌久
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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